Publications

PUBLICATIONS

Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons (2024)

ABell, A. M., Utting, C., Dickie, A. C., Kucharczyk, M. W., Quillet, R., Gutierrez-Mecinas, M., Razlan, A. N. B., Cooper, A. H., Lan, Y., Hachisuka, J., Weir, G. A., Bannister, K., Watanabe, M., Kania, A., Hoon, M. A., Macaulay, I. C., Denk, F., & Todd, A. J.

Proceedings of the National Academy of Sciences, 121(23), e2314213121.

Peripheral nerve injury results in a biased loss of sensory neuron sub-populations (2023)

Andrew H. Cooper, Allison M. Barry, Paschalina Chrysostomidou, Romane Lolignier, Heather F. Titterton, David L. Bennett, Greg A. Weir.

Pain 164 (12), 2780-2791

GluCl.Cre ON enables selective inhibition of molecularly defined pain circuits (2023)

Steven J Middleton , Huimin Hu , Jimena Perez-Sanchez , Sana Zuberi , Joseph McGrath Williams, Greg A Weir , David L Bennett

PAIN. 2023 Dec 1;164(12):2780-2791.

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling (2023)

Kieran A Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C Dickie, Andrew H Cooper, Andrew M Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I Hughes, Gregory A Weir, John S Riddell, Andrew J Todd.

eLife 12:RP86633.

Antibodies Against the Gastrin-releasing Peptide Precursor Pro-Gastrin-releasing Peptide Reveal Its Expression in the Mouse Spinal Dorsal Horn (2022)

Maria Gutierrez-Mecinas, Éva Kókai, Erika Polgár, Raphaëlle Quillet, Heather F. Titterton, Greg A. Weir, Masahiko Watanabe, Andrew J. Todd

Neuroscience 510, p60-71

Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice (2021)

Middleton SJ, Perini I, Themistocleous AC., Weir GA, McCann K, Barry AM, Marshall A, Lee M, Mayo LM, Bohic M, Baskozos G, Morrisonm I, Löken LS, McIntyre S, Nagi S, Staud R, Sehlstedt I, Johnson RD, Wessberg J, Wood JN, Woods CG, Moqrich A, Olausson H, Bennett DL

Brain awab482

Cellular models of pain: New technologies and their potential to progress preclinical research(2021)

Lina Chrysostomidou, Andrew H.Cooper, Greg A.Weir

Neurobiol. Pain 10, 100063.

The genetics of neuropathic pain from model organisms to clinical application (2019)

Calvo M#, Davies AJ#, Hébert HL#, Weir GA#, Chesler E, Finnerup NB, Levitt RC, Smith BH, Neely GG, Costigan M, Bennett DL

Neuron 104 pp. 637–635. #These authors contributed equally to this work

A causal role for TRESK loss of function in migraine mechanisms (2019)

Pettingill, P#., Weir, G. A#., Wei, T#., Wu, Y., Flower, G., Lalic, T., Handel A, Duggal G, Chintawar S, Cheung J, Arunasalam K, Couper E, Haupt LM, Griffiths LR, Bassett A, Cowley SA, Cader MZ.

Brain 1;142(12):3852-3867. #These authors contributed equally to this work

The role of TRESK in discreet afferent neuronal populations and somatosensory processing (2019)

Weir. GA#†., Pettingill. P#., Yu. Y., Duggal. G., Ilie. A., Akerman. CJ., Cader. Z†.

Frontiers in Molecular Neuroscience 12, 170. †Co-corresponding author

Defining the functional role of Nav1.7 in human nociception (2019)

McDermott. L#, Weir GA #, Themistocleous. A, Segerdahl. A, Blesneac. I, Baskozos. G, Clark. A, Millar. V, Peck. L, Ebner. D, Tracey. I, Serra. J and Bennett. DL.

Neuron 101. pp. 905–919.e8. #These authors contributed equally to this work

Immune or genetic mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability (2018)

Dawes JM, Weir GA, Middleton SJ, Patel R, Chisholm KI, Pettingill P, Peck LJ, Sheridan J, Shakir A, Jacobson L, Gutierrez-Mecinas M, Galino J, Walcher J, Kühnemund J, Kuehn H, Sanna MD, Lang B, Clark AJ, Themistocleous AC, Iwagaki N, West SJ, Werynska K, Carroll L, Trendafilova T, Menassa DA, Giannoccaro MP, Coutinho E, Cervellini I, Tewari D, Buckley C, Leite MI, Wildner H, Zeilhofer HU, Peles E, Todd AJ, McMahon SB, Dickenson AH, Lewin GR, Vincent A, Bennett DL.

Neuron 97. pp. 806-822.

Using an engineered GluCl channel to silence sensory neurons and treat neuropathic pain at the source (2017)

Weir GA, Middleton SJ, Clark AJ, Daniel T, Khovanov N, McMahon SB, Bennett DL.

Brain 140: 2570–85.

A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia (2016)

Sleigh JN, Weir GA, Schiavo G

BMC Res Notes 9:82.

C9orf72 hexanucleotide expansions are associated with altered ER calcium homeostasis and stress granule formation in iPSC-derived neurons from patients with amyotrophic lateral sclerosis and frontotemporal dementia (2016)

R. Dafinca, J. Scaber, N. Ababneh, T. Lalic, GA Weir, H. Christian, J. Vowles, A.G. Douglas, A. Fletcher-Jones, C. Browne, M. Nakanishi, M.R. Turner, R. Wade-Martins, S.A. Cowley, K. Talbot.

Stem Cells 34(8): 2063–2078

Cloxyquin (5- chloroquinolin-8-ol) is an activator of the two-pore domain potassium channel TRESK (2013)

P.D. Wright, GA Weir, J. Cartland, D. Tickle, C. Kettleborough, Z. Cader, J. Jerman.

Biochem. Biophys. Res. Commun 441 pp. 463-468

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex (2012)

BJC Janssen, T Malinauskas, GA Weir, MZ Cader, C Siebold, EY Jones.

Nature Structural and Molecular Biology 19 (12), 1293

New directions in migraine (2011)

GA Weir, MZ Cader

BMC Medicine 9 (1), 116

Commentary

News article